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ero}   !""#$% 7g	

LZnDu   !$( 
   I		dMbxJ`7kU8Ae J ^ "#Q#j###$%&   h	
^9U^/[t "a#7$$! i 		lI B:;B7S!"c""m$# Vt

=IS;hSNZ L!!!{#' @_	C`@nCd50	1 j !X"`"$' u 

9{%YJP`o}#] ":"y$$<&!   RN'aV	U{<c !!#U#$%D%N%U%% $

 VD_Z`Ij!#@$%%, sy 	

-1"7LT<"P"]"$$%%%7 	p5 ix y -P\ +3*0`H!"#h%U&' ?	 u)Q]U[3/8!s!.""$  	-
Kv/ Z#}$
& / a x  d	
!q? 	!%"e"#%!& 1
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g

{bA]2Yw+s=}(j !# `	+	"$% 	
p

p	Giz&9  !"i"N##$H&$ WEj,	
^f<xMSz?c !#$$4%>%,  b
+
+nt \2tv;=6!##o$$$<%(  ev]
ir,Q~K
(nw!!~"#q$%%%+ s"	2		cIi<?^lyEyD,Bo# A!!p#%U k	V	'
h_>_w<S:LR!-4I%XwilEKksU!!%#%% &1&% }
U~|1
31ktcdp!!#,$7%%%4&6    zqOs			8bUQ^*DN!y!o"/#*%n%s%%& H++,	!
O

7bq'   %!!!"}#?&Y&3 Rg_
i1H/M5t1= W!b!f!""##$%A%&0 F H\k*;.M'A@d2hT  )""d#.%&_&0 E{
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/j<^J  -!Z!#$* $ :  1LKe<	L
UU]SV$P,T!!"""#%! ' = \  
<kk!zJ 5"?""":$$$  3DS	B	{	mD&Wfw "*#$F$%   :&p	4
X
?!3A!""D#%$u$$$%%/ B	


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=[80rZ~7 ?!!#$C& }y		
g7L(HPR\(#s$$%%  "\C	5qs.<Bf""#4 U Y@!BX3{;V`f|9Z*J`'*b  E!##$%B  g0k$	4	Z	a	GPNYk{#!Eo
2N~vspu!"#Z%&)    u		7'u>lG@U%   "#$$|%" ZH_!o-f+23P ""r#%%2 $E?	UgtxK~MtRcoa{o{$'00>->~*!!"%&  n *W*$zEvhe ! [
Y ~Y $ 8^h	I		Z-[nSz  !$c%%  c

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  l !"4###$$9 E		0be cyrElu#8=Ol9BHQ`_ "Z"R##$%  '|V &!#$* .x8J

kB/T`pdO:YF@Du|% 5  C!""?#b#$8$.    e6.i		Ees8Yj0.7qt."#`#$$%0 h

B_8R:c4O_n"0\ K!!"W"b"$, 	

&`4C,;*_HG!i!!"#%#% ` }(=#\[8r!d""|$ W V	f
a*@yXr;Lyb "3%N  j!	1	*
;ms^J[~,H':kx<jrCAT5!!}""#o##n$%%)  |
a4Tb$!M!a!e!!!|##&3&>&X&% [DWu


TjT\L#5i1T !""#^&% %o	>JjH !!!>""$%%%,  !B <ZrU/6KI_&)Y-O[
>!'##$1 Y	`	wFL?Qb D	$,n#u1t2=O !$  
b
XY%)M}R}Xd  $2 A  <AM/aD<Ne6rGb|HW_	 k Y"$$# -w5
DjAo/N6Nm9
%!a"$%5 U	)

:|'Z+9Zwqa~ #{$ %2%    $n
[iG0,#!=! "="##=&  v~4X	XK>LMQMa$<^$* #mZK&hEF *KLp "!;"<"z$  8  GACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GCACNNNNNNGTTSAACNNNNNNGTGC,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNNNNTTYG,CRAANNNNNNGTC,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,TCGGTC,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,TTSAA,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GCTCC,GGAGC,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,CCDG,CHGG,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                        )                                                                                                                                                                                                                                                                                                                            =                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                                             
                                                 1                           *         
               	                                                                ,                                           
          	   	                             %                                                                                      
                	   	                     G   -                  
   	                           	      	                                              '      
            ,   N   3      3   4      1   ,   ,   !      o      +         -   #   /   %                        )                                                                                                                                                    =                                                                                                                                                                                                                                                                            
                             
                 1         *   
     	                      ,               
    	 	           %                              
      	 	       G -      
 	         	  	                '  
    , N 3  3 4  1 , , !  o  +   - # / %    *      >  b    g,%Z` 
u
AZ,bw#AX % CjI#ut v"s&h!%#:@
5Y	%A;[
Jj672u&/mq)5Gs6h!%%%%%5As{ ;!s{ s{ {{{{{C!"# Y	 u\	@g, w#9i 59i@9oD_9V@FD_`jTu-WD$ Yc" 5\ #_	:$_	7
*$?B!%Pajsx	"@	P
:yz# xy %CR4=$E!L#pFz"U&nu|
<"l0E#[*	:#Q#$%'3  
y	0]~<##%#%'!	R	^#%Fi	y|6$&#	:#%w@[ [tJA$8#!=&hA!	:#um% @	-	\	+P6i
!
:yz#5@ x(y  !I!"j$%4	K!=Ib#x e"% 9![|[AMX	f

m(Xjr1bYt3&R@BG",! !!
3+)F!)Bpj".4cx -p"e""%	S$%ja	Ry	0]|6~^<##%
;I 9$$y[AMj1	j7$%uM	-[ 7(
v{3O78mv")C2d!Y%%&&f
mXjrY< [ y$ rIU=izV[~ [ g g#x#cIf*	""C.<"mn  5#T]i S!	4	l0EK!#REKR{$%
5aoA?	

Bt #%a/j;F2X{?B1bJI L!9$$$B&g	/  S7ZX3)!	1	;mixo#A%&q!i&'=3Ib#$>"!\"`	
#"x% "IUiz[[ g#s>jW@ h 8"y#Fx	
@E>RL#$$K$|Y	`	
 Db	ut3& T6$$9!%Qf^
JL`szz&,)!"$%&	
E.g !o!!^"$%	
&`;!# %#%	"#$$:Ya D!#E!^"Qf^
Ls"$J`zz&,)!%&JH!!"7e*	`hx[_T&`?xqx  Qf^
Jor]L`&szjz&2i,/@)!|"""#$g%%&|	Y	`	

&` Db	;ut!# %#%3&A'!#j%%u	"%%OM"$!!!|#>&X&%&
G !"x/`O%   	'U"|%O&=V *x+N
e
)W:KSp "$%% x	'/U`O%  "$|%+,	'  %!"Y& "C5.<"qtg*
! e&DiwR>#=%)
:Z+9wq~QTC%M%%cy		
>F-Vo` 	f~)<xMz !E&R&  y
&t
7PY
7  c"n""$m%/aD<NG_Y" -LPwl!#%
7Qb3!J!"V"$6N+!\5&%+ aja
{Xmv	 !1""#
%-&A&u'	M	-k 	dbx7k8A ^ Q##$%Vc	-o a
Xm!"
%A&y	
>F`  or]&j2i/@|""#g% "+C,	5.<'  %!""Y&K		<
=+z 1 "
#	" b
+
+nt \2tv;=6!##o$$$<% j!	1	*
;ms^J[~,H':kx<jrCAT5!!}""#o##n$%% #Q,UoT^2/6K;O""?$%C%M%g%%%u {a)	
$1
y"y% 
6b8	
jp!_2Bx)> z!"U"$%&a&d	
&
H*v;]3u	$v+nv!!$#p$$;%%% n *W*$zEvhe !y  s_9JV>\j{5DW@\  \ h  &"8"f"h#y##%z	Jq.G!4h V !p!{"$%V&	

&`4C,;*_HG!i!!"#%#%' = \  
<kk!zJ 5"?""":$$$ 
+6(zb8C	G			`

-+6Jq
jpz#26IXdj!!_}.7G2!,4h7Brx )]r+> zVa! !I!c!g!p!!""U"{"$$%0%X%\%%%&V&a& ' = \   "$_%'3iDS	B	J	{					8
R

<mD-/k\ok!&Wfzw4J     	"5"?""""""*#$:$F$$$$d%%%+@


F]\v8 !M#$G& " Z  @>/@	w		


35db?+!!F""#$%& |	Y	`	


w&`a4FL?Qb4TC ,Db	$,;n#*u1_t2=HO $!G!M!a!e!i!!!!!"#|##$%#%&3&>&X& g}
U~0k|1	$	4	Z	a	


GP3N&Y`k1kt4{#C!,Eco
2N;~*vsp_udpH!!G!i!!!""###,$%#%7%Z%%%&4& Zo,anv}h		E


0Ak=#:Kr !"-w5
DjAo/N6Nm9
%!a"$%&rA	){v*0 !$ (MvO		r W4; o t   !!6#$_%$&p  
6b8	K+		@




]N2luFjp(]CP\|av!_.+2{Bx)> Nz18 c  !!"U"M#$$$$$%&G&a& 		
 e(t>P#   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  "A<?xml version="1.0"?><Features nextValidID="26"><Feature recentID="0" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6325-6329" color="#ffffff" type="standard"/></Feature><Feature recentID="1" name="CopGFP" directionality="1" translationMW="27559.88" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5929" maxFusedRunOn="5929"><Segment range="4520-5275" color="#00ff00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPKQGRMTNKMKSTKGALTFSPYLLSHVMGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVVGTGFPEDSVIFTDKIIRSNATVEHLHPMGDNVLVGSFARTFSLRDGGYYSFVVDSHMHFKSAIHPSILQNGGPMFAFRRVEELHSNTELGIVEYQHAFKTPIAFARSRAQSSNSAVDGTAGPGSTGSR"/></Q></Feature><Feature recentID="2" name="EF1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3961-4506" color="#ffffff" type="standard"/></Feature><Feature recentID="3" name="Factor Xa site" directionality="2" translationMW="473.53" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6400" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6326" maxFusedRunOn="6326" detectionMode="exactProteinMatch"><Segment range="6401-6412" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature><Feature recentID="4" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9805-9821" color="#a020f0" type="standard"/></Feature><Feature recentID="5" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7229-7245" color="#31849b" type="standard"/></Feature><Feature recentID="6" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7206-7221" color="#a020f0" type="standard"/></Feature><Feature recentID="7" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7298-7319" color="#31849b" type="standard"/></Feature><Feature recentID="8" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-10" range="7253-7259" color="#ffffff" type="standard"/><Segment range="7260-7277" color="#ffffff" type="standard"/><Segment name="-35" range="7278-7283" color="#ffffff" type="standard"/></Feature><Feature recentID="9" name="T2A" directionality="1" translationMW="1829.96" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5326" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5929" maxFusedRunOn="5929" detectionMode="exactProteinMatch"><Segment range="5276-5329" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="EGRGSLLTCGDVEENPGP"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="9227-9331" color="#ffffff" type="standard"/></Feature><Feature recentID="11" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1807-1923" color="#ffe4c4" type="standard"/></Feature><Feature recentID="12" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6897-7018" color="#a6acb3" type="standard"/></Feature><Feature recentID="13" name="HIV-1 Ψ" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="460-585" color="#ffe4c4" type="standard"/></Feature><Feature recentID="14" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7037-7172" color="#ffff00" type="standard"/></Feature><Feature recentID="15" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="233-413" color="#ffe4c4" type="standard"/></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2013-2216" color="#ffffff" type="standard"/></Feature><Feature recentID="17" name="3' LTR (ΔU3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6592-6825" color="#ffe4c4" type="standard"/></Feature><Feature recentID="18" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1078-1311" color="#ffe4c4" type="standard"/></Feature><Feature recentID="19" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5930-6518" color="#ffffff" type="standard"/></Feature><Feature recentID="20" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7607-8195" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="21" name="PuroR" directionality="1" translationMW="21496.48" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5330-5929" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA*"/></Q></Feature><Feature recentID="22" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9157" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="8366-9157" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9158-9226" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="23" name="Feature 24" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6469-6469" color="#a6acb3" type="standard"/></Feature><Feature recentID="24" name="Firefly Luciferase" directionality="1" translationMW="60644.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2293-3945" color="#ffcc00" type="standard" translated="1"/><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVDITYAEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMGISQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLIDKYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIKAKKGGKIAV*"/></Q></Feature><Feature recentID="25" name="kOZAK" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2287-2292" color="#a6acb3" type="standard"/></Feature></Features>
  <?xml version="1.0"?><Primers nextValidID="6"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40" showAdditionalFivePrimeMatches="1" minimumFivePrimeAnnealing="15"/><Primer recentID="0" name="K209-R1" sequence="gattatctcgaGCGgaattcttacacggcgatctttccgc" visible="0"><BindingSite location="3925-3952" boundStrand="1" annealedBases="GCGgacttacacggcgatctttccgc" meltingTemperature="59"><Component bases="gattatctcga"/><Component hybridizedRange="3948-3952" bases="GCGga"/><Component bases="att"/><Component hybridizedRange="3925-3945" bases="cttacacggcgatctttccgc"/></BindingSite><BindingSite simplified="1" location="3925-3945" boundStrand="1" annealedBases="cttacacggcgatctttccgc" meltingTemperature="59"><Component bases="gattatctcgaGCGgaatt"/><Component hybridizedRange="3925-3945" bases="cttacacggcgatctttccgc"/></BindingSite></Primer><Primer recentID="1" name="K209-F1" sequence="cccgcggccgatccaccggagccaccatggaagacgccaaaaacataaagaaa" visible="0"><BindingSite location="2284-2318" boundStrand="0" annealedBases="gagccaccatggaagacgccaaaaacataaagaaa" meltingTemperature="64"><Component bases="cccgcggccgatccaccg"/><Component hybridizedRange="2284-2318" bases="gagccaccatggaagacgccaaaaacataaagaaa"/></BindingSite><BindingSite simplified="1" location="2284-2318" boundStrand="0" annealedBases="gagccaccatggaagacgccaaaaacataaagaaa" meltingTemperature="64"><Component bases="cccgcggccgatccaccg"/><Component hybridizedRange="2284-2318" bases="gagccaccatggaagacgccaaaaacataaagaaa"/></BindingSite></Primer><Primer recentID="2" name="Primer 1" sequence="AATCAACGGGACTTTCCA" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2024-01-20T08:29:32Z"><BindingSite location="2120-2137" boundStrand="0" annealedBases="AATCAACGGGACTTTCCA" meltingTemperature="53"><Component hybridizedRange="2120-2137" bases="AATCAACGGGACTTTCCA"/></BindingSite><BindingSite simplified="1" location="2120-2137" boundStrand="0" annealedBases="AATCAACGGGACTTTCCA" meltingTemperature="53"><Component hybridizedRange="2120-2137" bases="AATCAACGGGACTTTCCA"/></BindingSite></Primer><Primer recentID="3" name="Primer 2" sequence="tcaacagtatgggcattt" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2024-01-20T08:29:57Z"><BindingSite location="2635-2652" boundStrand="0" annealedBases="tcaacagtatgggcattt" meltingTemperature="51"><Component hybridizedRange="2635-2652" bases="tcaacagtatgggcattt"/></BindingSite><BindingSite simplified="1" location="2635-2652" boundStrand="0" annealedBases="tcaacagtatgggcattt" meltingTemperature="51"><Component hybridizedRange="2635-2652" bases="tcaacagtatgggcattt"/></BindingSite></Primer><Primer recentID="4" name="Primer 3" sequence="caaagtgcgctgctggtg" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2024-01-20T08:30:30Z"><BindingSite location="3138-3155" boundStrand="0" annealedBases="caaagtgcgctgctggtg" meltingTemperature="61"><Component hybridizedRange="3138-3155" bases="caaagtgcgctgctggtg"/></BindingSite><BindingSite simplified="1" location="3138-3155" boundStrand="0" annealedBases="caaagtgcgctgctggtg" meltingTemperature="61"><Component hybridizedRange="3138-3155" bases="caaagtgcgctgctggtg"/></BindingSite></Primer><Primer recentID="5" name="Primer 4" sequence="atgattatgtccggttat" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2024-01-20T08:30:54Z"><BindingSite location="3477-3494" boundStrand="0" annealedBases="atgattatgtccggttat" meltingTemperature="47"><Component hybridizedRange="3477-3494" bases="atgattatgtccggttat"/></BindingSite><BindingSite simplified="1" location="3477-3494" boundStrand="0" annealedBases="atgattatgtccggttat" meltingTemperature="47"><Component hybridizedRange="3477-3494" bases="atgattatgtccggttat"/></BindingSite></Primer></Primers>
  B<Notes>
<UUID>4606d831-b611-4708-adcf-92a533f797fa</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="9:49:22">2024.9.25</Created>
<LastModified UTC="7:54:26">2024.11.14</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         Unsaved Enzyme Set                                                                                                    HO               E              Y?                                                                                                                                                                <?xml version="1.0"?><CustomEnzymeSets><CustomEnzymeSet type="2" name="Unsaved Enzyme Set" enzymeNames="BamHI EcoRI EcoRV FspI HindIII KpnI MfeI NdeI NheI NotI SacII SalI ScaI SpeI XhoI"/></CustomEnzymeSets>
