	   SnapGene      6ûgacattgattattgactagttattaatagtaatcaattacggggtcattagttcatagcccatatatggagttccgcgttacataacttacggtaaatggcccgcctggctgaccgcccaacgacccccgcccattgacgtcaataatgacgtatgttcccatagtaacgccaatagggactttccattgacgtcaatgggtggagtatttacggtaaactgcccacttggcagtacatcaagtgtatcatatgccaagtacgccccctattgacgtcaatgacggtaaatggcccgcctggcattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtctatataagcagcgcgttttgcctgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtggcgcccgaacagggacttgaaagcgaaagggaaaccagaggagctctctcgacgcaggactcggcttgctgaagcgcgcacggcaagaggcgaggggcggcgactggtgagtacgccaaaaattttgactagcggaggctagaaggagagagatgggtgcgagagcgtcagtattaagcgggggagaattagatcgcgatgggaaaaaattcggttaaggccagggggaaagaaaaaatataaattaaaacatatagtatgggcaagcagggagctagaacgattcgcagttaatcctggcctgttagaaacatcagaaggctgtagacaaatactgggacagctacaaccatcccttcagacaggatcagaagaacttagatcattatataatacagtagcaaccctctattgtgtgcatcaaaggatagagataaaagacaccaaggaagctttagacaagatagaggaagagcaaaacaaaagtaagaccaccgcacagcaagcggccgctgatcttcagacctggaggaggagatatgagggacaattggagaagtgaattatataaatataaagtagtaaaaattgaaccattaggagtagcacccaccaaggcaaagagaagagtggtgcagagagaaaaaagagcagtgggaataggagctttgttccttgggttcttgggagcagcaggaagcactatgggcgcagcgtcaatgacgctgacggtacaggccagacaattattgtctggtatagtgcagcagcagaacaatttgctgagggctattgaggcgcaacagcatctgttgcaactcacagtctggggcatcaagcagctccaggcaagaatcctggctgtggaaagatacctaaaggatcaacagctcctggggatttggggttgctctggaaaactcatttgcaccactgctgtgccttggaatgctagttggagtaataaatctctggaacagatttggaatcacacgacctggatggagtgggacagagaaattaacaattacacaagcttaatacactccttaattgaagaatcgcaaaaccagcaagaaaagaatgaacaagaattattggaattagataaatgggcaagtttgtggaattggtttaacataacaaattggctgtggtatataaaattattcataatgatagtaggaggcttggtaggtttaagaatagtttttgctgtactttctatagtgaatagagttaggcagggatattcaccattatcgtttcagacccacctcccaaccccgaggggacccgacaggcccgaaggaatagaagaagaaggtggagagagagacagagacagatccattcgattagtgaacggatcggcactgcgtgcgccaattctgcagacaaatggcagtattcatccacaattttaaaagaaaaggggggattggggggtacagtgcaggggaaagaatagtagacataatagcaacagacatacaaactaaagaattacaaaaacaaattacaaaaattcaaaattttcgggtttattacagggacagcagagatccagtttggttaattaaggtaccgagggcctatttcccatgattccttcatatttgcatatacgatacaaggctgttagagagataattagaattaatttgactgtaaacacaaagatattagtacaaaatacgtgacgtagaaagtaataatttcttgggtagtttgcagttttaaaattatgttttaaaatggactatcatatgcttaccgtaacttgaaagtatttcgatttcttggctttatatatcttgtggaaaggacgaaacaccggagacggttgtaaatgagcacacaaaatacacatgctaaaatattatattctatgacctttataaaatcaaccaaaatcttctttttaataactttagtatcaataattagaatttttatgttcctttttgcaaacttttaataaaaatgagcaaaataaaaaaacgctagttttagtaactcgcgttgttttcttcacctttaataatagctactccaccacttgttcctaagcggtcagctcctgcttcaatcattttttgagcatcttcaaatgttctaactccaccagctgctttaactaaagcattgtctttaacaactgacttcattagtttaacatcttcaaatgttgcacctgattttgaaaatcctgttgatgttttaacaaattctaatccagcttcaacagctatttcacaagctttcatgatttcttcttttgttaataaacaattttccataatacatttaacaacatgtgatccagctgctttttttacagctttcatgtcttctaaaactaattcataatttttgtcttttaatgcaccaatatttaataccatatcaatttctgttgcaccatctttaattgcttcagaaacttcgaatgcttttgtagctgttgtgcatgcacctagaggaaaacctacaacatttgttattcctacatttgtgccttttaataattctttacaatagcttgttcaatatgaattaacacaaactgttgcaaaatcaaattcaattgcttcatcacataattgtttaatttcagctttcgtagcatcttgttttaataatgtgtgatctatatatttgtttagtttcattttttctcctatatattcatttttaattttaattctttaataatttcgtctactttaactttagcgttttgaacagattcaccaacacctataaaataaatttttagtttaggttcagttccacttgggcgaacagcaaatcatgacttatcttctaaataaaattttagtaagtcttgtcctggcatattatacattccatcgatgtagttcttgctcttttttgtacgtctctgtttaagagctatgctggaaacagcatagcaagtttaaataaggctagtccgttatcaacttgaaaaagtggcaccgagtcggtgcttttttgaattcgctagctaggtcttgaaaggagtgggaattggctccggtgcccgtcagtgggcagagcgcacatcgcccacagtccccgagaagttggggggaggggtcggcaattgatccggtgcctagagaaggtggcgcggggtaaactgggaaagtgatgtcgtgtactggctccgcctttttcccgagggtgggggagaaccgtatataagtgcagtagtcgccgtgaacgttctttttcgcaacgggtttgccgccagaacacaggaccggttctagagcgctgccaccatggacaagaagtacagcatcggcctggacatcggcaccaactctgtgggctgggccgtgatcaccgacgagtacaaggtgcccagcaagaaattcaaggtgctgggcaacaccgaccggcacagcatcaagaagaacctgatcggagccctgctgttcgacagcggcgaaacagccgaggccacccggctgaagagaaccgccagaagaagatacaccagacggaagaaccggatctgctatctgcaagagatcttcagcaacgagatggccaaggtggacgacagcttcttccacagactggaagagtccttcctggtggaagaggataagaagcacgagcggcaccccatcttcggcaacatcgtggacgaggtggcctaccacgagaagtaccccaccatctaccacctgagaaagaaactggtggacagcaccgacaaggccgacctgcggctgatctatctggccctggcccacatgatcaagttccggggccacttcctgatcgagggcgacctgaaccccgacaacagcgacgtggacaagctgttcatccagctggtgcagacctacaaccagctgttcgaggaaaaccccatcaacgccagcggcgtggacgccaaggccatcctgtctgccagactgagcaagagcagacggctggaaaatctgatcgcccagctgcccggcgagaagaagaatggcctgttcggaaacctgattgccctgagcctgggcctgacccccaacttcaagagcaacttcgacctggccgaggatgccaaactgcagctgagcaaggacacctacgacgacgacctggacaacctgctggcccagatcggcgaccagtacgccgacctgtttctggccgccaagaacctgtccgacgccatcctgctgagcgacatcctgagagtgaacaccgagatcaccaaggcccccctgagcgcctctatgatcaagagatacgacgagcaccaccaggacctgaccctgctgaaagctctcgtgcggcagcagctgcctgagaagtacaaagagattttcttcgaccagagcaagaacggctacgccggctacattgacggcggagccagccaggaagagttctacaagttcatcaagcccatcctggaaaagatggacggcaccgaggaactgctcgtgaagctgaacagagaggacctgctgcggaagcagcggaccttcgacaacggcagcatcccccaccagatccacctgggagagctgcacgccattctgcggcggcaggaagatttttacccattcctgaaggacaaccgggaaaagatcgagaagatcctgaccttccgcatcccctactacgtgggccctctggccaggggaaacagcagattcgcctggatgaccagaaagagcgaggaaaccatcaccccctggaacttcgaggaagtggtggacaagggcgcttccgcccagagcttcatcgagcggatgaccaacttcgataagaacctgcccaacgagaaggtgctgcccaagcacagcctgctgtacgagtacttcaccgtgtataacgagctgaccaaagtgaaatacgtgaccgagggaatgagaaagcccgccttcctgagcggcgagcagaaaaaggccatcgtggacctgctgttcaagaccaaccggaaagtgaccgtgaagcagctgaaagaggactacttcaagaaaatcgagtgcttcgactccgtggaaatctccggcgtggaagatcggttcaacgcctccctgggcacataccacgatctgctgaaaattatcaaggacaaggacttcctggacaatgaggaaaacgaggacattctggaagatatcgtgctgaccctgacactgtttgaggacagagagatgatcgaggaacggctgaaaacctatgcccacctgttcgacgacaaagtgatgaagcagctgaagcggcggagatacaccggctggggcaggctgagccggaagctgatcaacggcatccgggacaagcagtccggcaagacaatcctggatttcctgaagtccgacggcttcgccaacagaaacttcatgcagctgatccacgacgacagcctgacctttaaagaggacatccagaaagcccaggtgtccggccagggcgatagcctgcacgagcacattgccaatctggccggcagccccgccattaagaagggcatcctgcagacagtgaaggtggtggacgagctcgtgaaagtgatgggccggcacaagcccgagaacatcgtgatcgaaatggccagagagaaccagaccacccagaagggacagaagaacagccgcgagagaatgaagcggatcgaagagggcatcaaagagctgggcagccagatcctgaaagaacaccccgtggaaaacacccagctgcagaacgagaagctgtacctgtactacctgcagaatgggcgggatatgtacgtggaccaggaactggacatcaaccggctgtccgactacgatgtggaccatatcgtgcctcagagctttctgaaggacgactccatcgacaacaaggtgctgaccagaagcgacaagaaccggggcaagagcgacaacgtgccctccgaagaggtcgtgaagaagatgaagaactactggcggcagctgctgaacgccaagctgattacccagagaaagttcgacaatctgaccaaggccgagagaggcggcctgagcgaactggataaggccggcttcatcaagagacagctggtggaaacccggcagatcacaaagcacgtggcacagatcctggactcccggatgaacactaagtacgacgagaatgacaagctgatccgggaagtgaaagtgatcaccctgaagtccaagctggtgtccgatttccggaaggatttccagttttacaaagtgcgcgagatcaacaactaccaccacgcccacgacgcctacctgaacgccgtcgtgggaaccgccctgatcaaaaagtaccctaagctggaaagcgagttcgtgtacggcgactacaaggtgtacgacgtgcggaagatgatcgccaagagcgagcaggaaatcggcaaggctaccgccaagtacttcttctacagcaacatcatgaactttttcaagaccgagattaccctggccaacggcgagatccggaagcggcctctgatcgagacaaacggcgaaaccggggagatcgtgtgggataagggccgggattttgccaccgtgcggaaagtgctgagcatgccccaagtgaatatcgtgaaaaagaccgaggtgcagacaggcggcttcagcaaagagtctatcctgcccaagaggaacagcgataagctgatcgccagaaagaaggactgggaccctaagaagtacggcggcttcgacagccccaccgtggcctattctgtgctggtggtggccaaagtggaaaagggcaagtccaagaaactgaagagtgtgaaagagctgctggggatcaccatcatggaaagaagcagcttcgagaagaatcccatcgactttctggaagccaagggctacaaagaagtgaaaaaggacctgatcatcaagctgcctaagtactccctgttcgagctggaaaacggccggaagagaatgctggcctctgccggcgaactgcagaagggaaacgaactggccctgccctccaaatatgtgaacttcctgtacctggccagccactatgagaagctgaagggctcccccgaggataatgagcagaaacagctgtttgtggaacagcacaagcactacctggacgagatcatcgagcagatcagcgagttctccaagagagtgatcctggccgacgctaatctggacaaagtgctgtccgcctacaacaagcaccgggataagcccatcagagagcaggccgagaatatcatccacctgtttaccctgaccaatctgggagcccctgccgccttcaagtactttgacaccaccatcgaccggaagaggtacaccagcaccaaagaggtgctggacgccaccctgatccaccagagcatcaccggcctgtacgagacacggatcgacctgtctcagctgggaggcgacaagcgacctgccgccacaaagaaggctggacaggctaagaagaagaaagattacaaagacgatgacgataagggatccggcgcaacaaacttctctctgctgaaacaagccggagatgtcgaagagaatcctggaccgaccgagtacaagcccacggtgcgcctcgccacccgcgacgacgtccccagggccgtacgcaccctcgccgccgcgttcgccgactaccccgccacgcgccacaccgtcgatccggaccgccacatcgagcgggtcaccgagctgcaagaactcttcctcacgcgcgtcgggctcgacatcggcaaggtgtgggtcgcggacgacggcgccgcggtggcggtctggaccacgccggagagcgtcgaagcgggggcggtgttcgccgagatcggcccgcgcatggccgagttgagcggttcccggctggccgcgcagcaacagatggaaggcctcctggcgccgcaccggcccaaggagcccgcgtggttcctggccaccgtcggagtctcgcccgaccaccagggcaagggtctgggcagcgccgtcgtgctccccggagtggaggcggccgagcgcgccggggtgcccgccttcctggagacctccgcgccccgcaacctccccttctacgagcggctcggcttcaccgtcaccgccgacgtcgaggtgcccgaaggaccgcgcacctggtgcatgacccgcaagcccggtgcctgaacgcgttaagtcgacaatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaaatcatcgtcctttccttggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtcttcgccttcgccctcagacgagtcggatctccctttgggccgcctccccgcgtcgactttaagaccaatgacttacaaggcagctgtagatcttagccactttttaaaagaaaaggggggactggaagggctaattcactcccaacgaagacaagatctgctttttgcttgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagggcccgtttaaacccgctgatcagcctcgactgtgccttctagttgccagccatctgttgtttgcccctcccccgtgccttccttgaccctggaaggtgccactcccactgtcctttcctaataaaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggggggtggggtggggcaggacagcaagggggaggattgggaagacaatagcaggcatgctggggatgcggtgggctctatggcttctgaggcggaaagaaccagctggggctctagggggtatccccacgcgccctgtagcggcgcattaagcgcggcgggtgtggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcccgctcctttcgctttcttcccttcctttctcgccacgttcgccggctttccccgtcaagctctaaatcgggggctccctttagggttccgatttagtgctttacggcacctcgaccccaaaaaacttgattagggtgatggttcacgtagtgggccatcgccctgatagacggtttttcgccctttgacgttggagtccacgttctttaatagtggactcttgttccaaactggaacaacactcaaccctatctcggtctattcttttgatttataagggattttgccgatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaacgcgaattaattctgtggaatgtgtgtcagttagggtgtggaaagtccccaggctccccagcaggcagaagtatgcaaagcatgcatctcaattagtcagcaaccaggtgtggaaagtccccaggctccccagcaggcagaagtatgcaaagcatgcatctcaattagtcagcaaccatagtcccgcccctaactccgcccatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctctgcctctgagctattccagaagtagtgaggaggcttttttggaggcctaggcttttgcaaaaagctcccgggagcttgtatatccattttcggatctgatcagcacgtgttgacaattaatcatcggcatagtatatcggcatagtataatacgacaaggtgaggaactaaaccatggccaagttgaccagtgccgttccggtgctcaccgcgcgcgacgtcgccggagcggtcgagttctggaccgaccggctcgggttctcccgggacttcgtggaggacgacttcgccggtgtggtccgggacgacgtgaccctgttcatcagcgcggtccaggaccaggtggtgccggacaacaccctggcctgggtgtgggtgcgcggcctggacgagctgtacgccgagtggtcggaggtcgtgtccacgaacttccgggacgcctccgggccggccatgaccgagatcggcgagcagccgtgggggcgggagttcgccctgcgcgacccggccggcaactgcgtgcacttcgtggccgaggagcaggactgacacgtgctacgagatttcgattccaccgccgccttctatgaaaggttgggcttcggaatcgttttccgggacgccggctggatgatcctccagcgcggggatctcatgctggagttcttcgcccaccccaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctgtataccgtcgacctctagctagagcttggcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaagaacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtcgacggatcgggagatctcccgatcccctatggtgcactctcagtacaatctgctctgatgccgcatagttaagccagtatctgctccctgcttgtgtgttggaggtcgctgagtagtgcgcgagcaaaatttaagctacaacaaggcaaggcttgaccgacaattgcatgaagaatctgcttagggttaggcgttttgcgctgcttcgcgatgtacgggccagatatacgcgtt  I²  ¥GACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GCACNNNNNNGTTSAACNNNNNNGTGC,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNNNNTTYG,CRAANNNNNNGTC,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,GDGCHC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,GCCGGC,CAATTG,ACGCGT,TCCRAC,GTYGGA,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,TCGGTC,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,TTSAA,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GCTCC,GGAGC,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,RGCR,YGCY,YATR,ACGT,TGCA,CCDG,CHGG,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                       0                                                                                                                                                                                                                                                                                                                   Y                                                      
                                                                                                                                                                                                                                                                                                                                                           	                                                                                                                 	                                                 	                               	            
                                                                                                 	                  3   #                        	   C                                    	                                                 A                                     
                  	   
                     ,   7   
                                                 	            	               :         3   2                                 `   W                     	            "   &                  
       #   +                  '         
         -                  /   J   B   +   U   6      S   Q   H   #         �   "   3     ê   J   '   @   C   Ò   /                 0                                                                                                                                           Y                        
                                                                                                                                                               	                                               	                 	           	    
                                 	      3 #        	 C            	                 A             
      	 
       , 7 
                 	    	     :   3 2           ` W       	    " &      
   # +      '   
   -      / J B + U 6  S Q H # � " 3 ê J ' @ C Ò /  U   WX  W¼  Xd  a(  kz  €Êš(]/”Ë#”kD¯"o(\,: Meõö@~F§áÂìI×”4¤“9b~Œ!Ô!
"+"˜#Ë#.$s$Ï$Ú$�'Ö(*ž+¸+¹+¾+Ð,Y.//¿/Ö0Ço2û°p)¸)Q,X¾­ (0„*Åæ5•FÖ’0Z6Ä”„Ö  ×Æ>"3)Ç4ž+—
 ï'\x4"AÅê!ˆ+.I/c Ý $fK!Î!+,æ25ž+2G*��­sÝ! (ì+d.2jåã®"z)Â)@áìc Ý ý $�™C¨VýÈ!24juÎ£Hœ9ðâå/x“–Úã„‡¤fyB†oš£Õ/˜_½
 ‡ Á !K!x!ª!Î!×!;"®"·"ª#$$($„$à$ì$ü%E']'š'œ'Æ'á'ÿ'z)Â)õ)D*J*++,ñ-.q.´.&/b1æ2Î6I“ÈÄ¢Þ/š’%ö%àÓÇ4 8$Á*o2¹2àÓGÇ4 ö&Á*í+o2àÓÇ4 Á*o2ÓG4 4 Ó®*x°“l34r5È!È!`)¨)/è!!ª1¡(õ4Äê\ùá sÝ!á ¶™Iè Äs ž+‘›+¡+ì:hìì!=GÀÈÄs ª ž+½‘›+¡+,Ì¬7I[è 6àÍ*1 6#+:hì!=d&Ì4	q+6p¨£ Â�:Š¥Â6|.âÿ ì °"–)£+C	–ÆŒ5à]&U"W%Ž�izv½%®*‰X%«*°*á3¿�1åÚ15Ò© YÂÝÚâ
r T"ñ#|+�+ ,·,YÝÚr T"�+ÆŒàw
ï(	-Â!|*ˆ ½ Ê£ •"¡$*+
6PË¯Ú"-%z-�-6:Kê P3ª'�ÇZu÷<	ô	øoR4à<	±ñ<7AjH!Ë!I"�"È"¾&H(ª+÷-@2ß'Á-=®=ú ž!z"4+².»5«U3Ê4öîQ=GmÙ<Vjî”!¬!î!9"+,K,c,V.ø3„Û			ª
Á#á!ÇDó"()*-Ž6Q§úˆèÔ!v~1p’èÙ5Í¹*w,ˆ ½ ÊTeu§£ H!Ë!•"¡$*+,¼,Œ4
6Þ”è%Ñ"º*v,÷.ó6Ó Ò„+v5K
¼]¥&"±#Ê%+Y,10º45/6±#Y,105/6~ÃŠ”*N+X+5^& ‡	5)Å*.L.3*œÍ¿ò85ÖJ"ž"±#J$&^&Y,105/6ö=Ù<Vjî!+: v5{5¥ƒ]$!Þ!=$Ê%^&S'w'&(H:jZÝy¨¤/5H!Ë!Œ%3'<÷$´¨A')Ç)ƒ'+#È/¿5$Ë«¶—æp&²*RZX¦%5*¡2NÕ|ÿ�Yw3M%’' 0¿0e3Þ¡–H!Ë!"Ò'Ú'y.ë/häQ%“%¼%6à‰<	±ëñ<p7zA×—1j5�„\: H!¢!Ë!Ý!è!I"�"È"Ý%^&¾&'(3(H(c)«)ª+÷-/</@2ž2Ç2š3è5v¿5K
ò8{¼5Ö]¥ƒ]$!Þ!&"J"ž"±#=$J$Ê%&^&S'w'&(+Y,10º45/6V"ã,WÎ,É2ªþ%g0a/|1à4ã3Vª%Y"·2a­	0ŒÍo(¹*w,wqéÈq®‰º@	è™ù¿ÕXÈñ“nÆ@x!«ÒÓ=JHw9oÆ>È‹‰ © ª L!Ù!
"+"E"$X$x$Ô$Å%¶&_)§)"*E**”*þ*X+¸+¾+,,f,ò-—/¿ŸH-8
î9ÓÏl:K„ê +Å/X0—3ª2bØ#`3Ó]šo¸¥�*ÂÓ!à$(I+r+,M,¿,Ä2V@"$+2 ‹#l*h,f#9"K,;‘Th)°)Ož+ŠåE's''0…ºšËÐW[‚z 9"7+G+K, .H0ã3x4± d<
wè"*þ*ÎÝ6çÇ1·5÷.z-wÈq®ºèùX“wÈÙ!x$"**þ*!î$}.‰5â}©+="xˆj c $¤LVo´ÍH+4Òè1B¤Uo¸�ë¨ *l1‹!ª!à!@"L"À"$$-$€$Ù$à$ø%Œ&='A'Ï'Ý'(l))´)Ç)$+,$,M,W,¿,&.C.°./+/[1â2‡6wè«H>‰ L!$X$Ô$"*þ*,,Z
´¨A')Ç)÷.ahßO'	Òä¿6×H: %Q%“%¼%3&­*Ù,x1ƒ1Ù1å1å4ö46Ðß6l
$é&{(—ý3�°kã%D-".4”*X+L!Ô$›×	ä	Œ'`%e&ì1ÿ1³4.�$e'	sœò)***?/Ñ/3v5¥Ê%%Q§úˆèÔ!v~V"ã,1pW’èÙÎ,É25¿	!	æJj)²)�0`1²€)nÑ‘ê\æIˆR 2$Û$1Ç�)É)ø ó	Ú"-%¾*+�-6÷6¢Îáö%Ö (P^Ë“	¯Ti¨þX”Qƒ�VŸ�¹ºÌZIŽÚ"±#-%l(£(´(¾*+õ+Y,z-�-10256/6÷6;Îœ×ç×}ÙiàÜ{®zø9c“æ4©Í9)§:*K]ºªÀûê X!è"`*@+3.à/f0È0*1}1Ç1Ê2·56 6Ý6o¸�*à$(,M,¿,0(2°6Ñ"ó6bî­µ/m0Çö!%�(é+q6
]#‹-J“é�€…VF¯ŸãL!/$Ä$Ô$J%l&q'E.K0@1í4˜ð|5�!–!;"D*á+e,ï2H€"@$|ÿ�Yw3]#-“é€…VF¯ŸãJ%q'E.Ú"-%�-6”ªè%þ%a/g0|1à4c
f–5äNÑ[Öæ .Äw { D+,y4ª6Ý(Ÿ.Ú3è 8YŒOÍ¤	jô0öôo	øo€ £%R496W%^~1	²%Ò%²')-4Ùy}dÒ�Õ: %­*Ù,x1Ù1å46àP(	7À7ØIé²; è 4&Ê,.1„1æ1¶3÷4$6³Y*	
4I”¨Ð&Ä§ÅÙGÛb’È)k&Ê0|5“5�5É5h )qé4Ye‰ñ4$ÀÈìÄ9ZÆ@UyÓÞ>J”Û:h¼ìs ª È!ì!
"U"±"w#‘$Å%·&`)—)¨)ž+¤+¹+¾+Ñ+ò-/‹/˜/¼Weßü!�#«%´5DJ<
«_ÎY"·2@¾ÓS_%á•åèë“œ°ÏÚ„s0XEH‡¤ð!³!"1#1$}$Ý$I%»'(,-G.˜.ª.M0Ž0‘0_1§24×6b ##D	Ñ½ÃØË.—Ç�¡56X¶‘»…áGv ­ í [!Š!Ö!§"•#¹$È$%^&_&w(C+z+›+¡+,ž2í2þ2Ü3è6¢Õ™Ã¼ãoˆ¦!,"E"Å"ò#”*•*X+Y+}+,,I,¸,r0*3‰4{ve(ð*N4?5òÿ
Î'�sú’À!‡"�"+ß1Â205ÑÇ�¡X‘»áv í [!§"È$C+z+›+¡+þ2Ü3@¾ÓSåèœ°„s0E¤³!"I%»'(,-Ž0‘0_14_%á•ë“ÏÚXH‡ð!1#1$}$Ý$G.˜.ª.M0§2×6j…FGz@^iVpQá•¶'~‘&z(÷)˜2334¤Òõôc³¼!h(\},h­W¼ò¾Bf)F!$F(Ý0¥ „¯  "++,@m	¾ÓS_%Ãá�?®L•Sâåèë“œ°ÏÞáÚ?„�s0XBEH†RÕ,‡¤ðeû¾ Á !K!®!³!Î!"8"|"1#!$1$}$Ö$Ý$é$ %I%—'¥'»'J*Í+(,’,-G.˜.ª.­.#/¾/M0Ž0‘0_1§2ú34t4Y5K6×6h )qé4Ye‰ñ4¢$ÀÕ™ÈìÄ9ZÆ@UyÓÃÞ>J”¼Ûã:oˆh¼ìs ª ¦!È!ì!
","E"U"±"Å"w#ò#‘$Å%·&`)—)¨)”*•*X+Y+}+ž+¤+¹+¾+Ñ+,,I,¸,ò-/‹/˜/r0*3‰4®2LDQúf³%¿ˆ!½è&ƒ)Ë)#-O/k3#5~öK'=4H6RsZXm�š>“D#Í#r%¦%Å(Š0—0K46+	=G*+/.1¢23C3ú4Y6ôõX²æJ'Æ,k‘_jyW´&À2‰@ø)`2344åÉá%9&
0£1I266l…oÃq}žð;©‹¤À%ô&a'W*e4|6° Gï],ý	Åõô#Ÿ$o%[++,º,¦ ±$\)¤)ä)Y Ó ,—åB·�	ü	?
�üw9“•=‹ â ó!‰"µ#|&Ê&‰(~-Ñ./î0'2*4lå…!…oÃq}žð;©É‹ï¦¤ õá %U%À%9&ô&a'W*
0£1I2e466|6Ã6õ˜¸ú”I&+¥1:2£2þ3�°k8´#Ì#M$ã%É&D-".�.‰0–04?ÞTeuó§Á#,¼,]/Ÿ1±Ö!j!õ$+%�4d ~ %2x› Ó Œ!á!M"f"½".$Ó$(%k&Þ'æ)û)'.¾O‚ü r!�$¨'4,Õ,`.©ÐF&aæ/S	Ë·O§Ýßã±o ú!•$%$&¡(·(‰,®,R.“.Þ.j0o2¼6>+d¸rðöt†ÑòŸ ¢ ä  !D!k!õ!""”"—",%)+,+ƒ+€-\/v2}366kæFr| ”x‰²bî­ÊÓr3X*÷!%%¿%:&ó&`'6(V*«*°*ê+«,g/µ/1œ1#2á3ì3d4E6oW	 ¤6iQ"r"¦$´$Ë$Ï$þ$‚&¬&ó'–,Ý/1×3šI(7FüÔƒ˜òÖ>8€ À!¤"v%»&ê2N5V†,ìq…("#ê#á'((d)¬)‘*=/Ÿ/ 0È2•3Ô3b6u4£»z1\Ý!É%˜*3+j,M ¤ Î×°	ÿ	ì
t !Œ""&+&´'À'‡+-\0›01*2u3¯3H45â},14m©·ºÊ+¡¤=è¿"û"-06Úx®ˆ  j Œ%3'é0�1¹6‰
ü
G’ï=çJ!ï$ø$î'ê,~.Ü1Ï45Š5·ãú!%¡(j0©ÐF§Ýß$&·(“.o2Î°	t !Œ""&À'‡+u3H4&aæ/S	ËO±o •$‰,®,R.Þ.¼6m	Ã�?®LSâÞá?�B†RÕ,eû¾ Á K!®!Î!8"|"!$Ö$é$ %—'¥'J*Í+’,­.#/¾/ú3t4Y5K6�õ˜°k¸ú8”´#Ì#M$ã%I&É&+D-".�.‰0–0¥1:2£2þ34H4è œ,P.ø1·63 ž�Y	ƒæ7K/{�L¨£^#�+^2�3bÇÓs56›ªW$64J DWÏò
NW� Ã Ú !!>!M!Ž!°!ã!A"a"«"Ò"œ$Õ$ô$*%Œ'¤'¸'0)#+%+'+˜+Ì+D,Ô,]._.%/j1´2¡4í5†6Þ6ô6I e q  &
û
tÄ±T#�3y‘füœ ¿ Â Ô ð L!�!¯!Ï!â!N"`"g"�"ª"¾""$/$Ô$ó$!%)%l&Ä'ß'ç)ó)ü)***K*"+�,“,Á-(.‚.$/@/¿/Ò/K0@1³23û3 4í4Z5ì5L6�¢m�¾%O�?®Lâ/–ŸÞá°?��‚B†×RšÕ,ü ?!N!T!r!x! !8"|"$�$Æ$Ö$é$N'f'—'¥'¨'6+™+Í+4,Õ,`.j.­.´.É.¹0I1Í3t4½5é 9Z�*P{èÎµ=	¥	akõ1r@÷ïõjp‹ó¡¼Î
'ùepŽÊ� ² ¤%Ý+S4:6ä6w£6bÏ¥U…+^ÍÖâ$3«ûGrÐ.”Ùê€Î¥	�†³¦*WfÎGV°+©†¦ï| ä!é#K%Ë%÷%r'()Z*�*š*Ù+-‹-‘-§-.F.¼.ž/ø/&0'103”3Ó3•6CVXÑ*sMß¢—VA � Û !I!�!±!Ì!"@"B"b"¬"›$�'š'£'¹'Ó'Û'$+&+—+Ë+C,Ó,.^.z.›.©/ì/P0þ0k1ô2Q3¢4î5…6Õ6 …Û�—Äã
¼—ÎÒAÚÙ%/&X&†&|'Ø'€*M-‰-�-æ0ã123iàÌz‰~Pe(	g7%vÓå´ÌäŒ4Ž¬ÀÂãN·Ñ7ÃØ\˜àI[v�çÅÑé²Ö; è †!%R%”%½%4&q&®*³*,Ê,Ú,.1y1„1Œ1Ú1æ1O2¤3¶3ä3æ4÷4566$6b #ç7í#E	ÿ�÷c¥½ÃÙ\«Ìï.R—6>OHn·Ú{ˆœ=T†BW#Gkï4Å® Š!•!­!Ã!Ö!ï!:"•#¹$Ø$ë$%_&x()C*I*}*+¼+Ï+,,L,d,W.//"/Ô0ž2î2ù3é69
ï:Ô^£ÐÕš m·›®ÃÑFp¹¦ž½ä;Loˆ+…Ã> _ ë c!§!Ô!-"E"Æ"ò#á$	(•*+1+J+Y+s+}+®+,,,J,N,¸,À,Ý-Æ/Y0s011Å2ç2*3˜3Š4<xP	[
è9µéÉ©™’!¸"F#B'€)È)#*ÿ*,ß,s-ž-ø.È1³3½34/4¸5¶68 b k #ow˜£6K•ç7LbÏ¥í Uh…Š°#E	q	
+^ÍÖâ$3«ûGr•Ðëpÿ|—�¥÷c¥°½ÃÙ.\”«ÆÌï.R—Ùê"37S€Î6>¥ç	0O�Y†�§¬³ô;HTnu¦·ÁÚ*2Wf¨ÎGV{ˆœ °+©þ=T†×.7BW†¦ÆÍï#Gko|„ ï$4^Åä	  ] † ® !%!Š!•!©!­!Ã!Ö!ß!ï!:"~"ƒ"Ã"Z#•#é#>$C$|$¹$Ø$ã$ë$%K%X%z%Ã%Ë%Ó%ì%÷%_&u&�&T'\'r'x'(('(x())c)«)&*C*I*Z*q*}*ƒ*�*š*+L+¼+Ï+Ù+,,*,L,d,§,Â,-‹-‘-§-Û-ð-.F.W.©.¼.//"/</ž/ø/&0+0D0“0Ô0ß0
1'1’2ž2Ç2á2å2î203Š3”3Ó3ù3W6•6¥6é6å ,V‰˜¡à%?B"U^elo�°½œæiu–½ÀÇÐÕ
)1KR\<gçiˆÖ"	L
Ò
$CmP¾ÿ7�†±ÿ0LÞù>S`eŒ�ì8>AOšë KNrxœá8t¡½äç.j›ž¯²àãKf–¯â>AE~¹×ƒŒ�£¾ËÓN^r‡» /�û
AD…Ž¿ËÒ±ÀêîùDQh§ÔÝû+g£-—¯µÍÕ0•¼ìó@ û 0!H!S!i!q!w!Ÿ!µ!Ë!"""7"?"{"¡#©#Ö#$K$Å$H%Z&'!'<'@'e'–'™'¢'§'½'Ò'Ú'H(k)o)~)’)³)·)Æ)Ú)·*Ï*Ü*5+–+#,',3,P,l,Ò,-"-9-–-â-i.y.¯.³.È.þ.	/./N/o/Ž/æ/ë/�0�0¦0«0¸031H1^1a1@2L2Ö2ó2j3ª3Ì344v4Œ4«4Ö4"555C5Q5m5¡5¼5Š6 6Í6f r € ¨ Ü ü '3oK’§°ÀO~à™³¸ÂÊt÷	]
á
1a'�¢ã,Vw¾Ìó>u¤ÂÅàã9N�²×GVh�—¿ø*CUgo£Òíw’ÕS˜žÊÙÜë4]¡Íç,fùezÆðJQnwƒ’ã‘¢«í	M‰ò)Lõdg¢©úýS ‘ – ½ À É Õ Ü ñ J!a!€!Í! ""'"C"K"O"c"‘"Ÿ"Ê"###0#3#;#H#N#}#½#Û#ü#$ $#$'$,$0$3$$ƒ$Œ$«$Ü$ß$ü$%"%˜%Ÿ%æ%û%&&m&€&‹&�&ª&À&D'Ž'Å'Î'Ô'Ü'à'é'þ'(@(~(’(ü(è)ô)ý)	***L*R*++/+q+¬+à+,=,{,‘,”,¾,á,î,Â-ù-.%.).B.{.ƒ.‹.—.œ.*/A/_/ª/½/À/Ó/í/þ/0L0Q0†0½0ÿ01A1¡122j2¦2¿23(3A3]3c3y314?4�4‡4£4»4î4X56B6J6a6h6z6Á6Ö6Ù65 < > @ Q ˜   ø ú 1<Dx9;û	�‘'ACIÌ’” ÖÐßP	[	c	e	ß	ó	õ	
 
[
h
o
x
±
è	9Mrµ6km‰‹Ù9>uƒ“•éÉ©Ûdˆ¿©™Wu’!¸"#&#F#W#p#ˆ#B'Y'ð(w)€)¿)È)à)#*;* *Ñ*Ö*Þ*ã*ÿ*,›,ß,
-s-{-ž-¤-Õ-ä-ø.8/�/õ/²0È1222d2‡3³3½3444/4q4¨4…5¸5Ä5+6O6¶6ð6‰ • ¾ bË®	³	c¬1�ÎÓ¤ –"¥#¢$¯$(p(›(§(º*++…+x,¶1V3Ë46­†:«}»a	Ñ	½
�`�³·›Þ Ñ
XŽZxÌ4
!¶"²#ç&y)‚)Á)Ê)=*‰*Z,-G-I.20Z1©23Ä34506´6h )6Mfq/é49ïYe‰ñ:+	9
/\¡°Ë"4ï:ÇÔ<^s£´ÃÐ$„«ÀÕáð,Ibj’š­¹ÂÈÎì(1=I^m|�ÄÊÐï 59Z�½Æù@U^y¡Èé:[m·Ó3l›®ÃÑÞç 5>FJVpŒ¹Üæï4:Umv”¦ö`Šž½Ûä ;G}•:Loˆëäÿ+Jbhm¼ìFOb…“¯¸ÃÇÜø> _ s ª ë c!§!È!Ô!ì!
"-"E"U"±"Æ"Ì"w#ã#ò#%$…$‘$Ã$Ú$á$º%Å%�&·&p'‘'Ð'	(�(`)i)—)¨)±)*a*•*++1+J+Y+s+}+Œ+ž+¤+®+¹+¾+Ñ+,,,@,J,N,¸,À,Ð,¯-Ý-ò-/.;.D.//G/‹/˜/°/»/Æ/Í/Y0s0111l2¢2Å2Ë2ß2ã2ç233*3C3˜3Š4ú4356Y6f6ë6i *S]r}ÔCtê5[wÂëþGZfŠ�Øòé!½	9
5yï:YnÏÔP^£Ð%‘»ÁÕ�šÉí ,PÅ :[Çå<AVzm·Ô›Ÿ¥®ÃÑß?FKlp¹,•›¦?”ž²½Üä-;«ð;LoˆÒO‹Á	!+Ei½íü2Y…¤Ãæ  > _ t « ë Y!c!§!«!É!Ô!í!""-"E"V"²"Æ"é"#x#Ÿ#Î#ò#5$:$’$á$s%§%±%Æ%Ñ%(&\&¸&	''>'F't'	(Æ(a)m)˜)©)µ)•*+1+A+J+Y+s+}+Ÿ+¥+®+º+¿+Ò+,,,J,N,n,¸,À,Ä,ã,Ý-ó-â.î./,/{/Œ/™/Æ/(0Y0s0‹0˜0Ÿ011C1œ2Å2ç2*3h3˜3L4Š4<5K5ª5" …ÇÜÿ1>Wõ(QZt†™x˜íú	
	6	€	†	Š	Á	Ü	¥
«
ÂIPx�î
$)9A˜ž©â"Èç3Eîô"T$~%ä&))4)8)Š)Ò).*Ä*+-¸-É-.ð1"3!4�6±6šä¢	¥9ÏÈV%O“ º !Å!]"m"æ"h#$¼$í$%$%î%8&w&¡&L(N*T*	,Í,†-ˆ.£/3ß332ch“ß *'®B	¿(�›.^è6óp‹i„#‰@R-%ƒÈô�‹žê5"›"‹#ß&*'c'A*G*l*o*{*ó*f+í+h,g.j/®0>2�2u6 •ºã/	&{¼œ4	8	ˆ	Ø	å	‘
Æ
ewŒ¼ù\k‹é?[–œ¤¶m�(Ö"#7#4%a%é%f&Ÿ'®()!),)6)Æ*.M.¹1í1ò1 252 3G3´4T6’6‰ • ¾ @bË4w£6bÏ¥Uv…ð¸9;	®	³	s
+^ ÍÖâ$3«ºÆûGÖîcrÐÔH¬6Krü_ƒªï$.”¸ë'H]ÉÙê€�£ÅÎ1¥ÇÖ	Z�ak†³$@š¦*Wflu�Îí&GV°Î+|©ÊÓÉ†¦ãïg| »EŒŸÛä÷¤ !4!\"l"–"œ"°"å"¥#â#é#�$¢$¯$Ê$K%Ë%÷%½&ú&r'((K(p(›(§()™)Z*�*š*º*ï*++…+¦+Ù+î+x,¡,-…-‹-‘-§-.:.F.¼.k/ž/Ì/ø/00&0¯01'1¶1á1C203V3”3Ó3Ë466v6•6=W
�I‡æ4è§‚¬¾œ¥PqÓäk]2ª¹Ê�Øh æ ø (!m!™"Û".%y&N(:+‡,‚-[/ÿ46  Ì<Notes>
<UUID>15282c50-3b5e-46a2-988d-48b4f518d1ea</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>LentiCRISPRv2-Opti</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>LentiCRISPRv2 variant with modified sgRNA scaffold from Chen et al. 2013 Cell..</Description>
<Created UTC="4:0:0">2025.4.14</Created>
<LastModified UTC="4:0:0">2025.4.14</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference type="Journal Article" pubMedID="33208952" authors="Adelmann CH, Traunbauer AK, Chen B, Condon KJ, Chan SH, Kunchok T, Lewis CA, Sabatini DM" title="MFSD12 mediates the import of cysteine into melanosomes and lysosomes." journal="Nature. 2020 Nov 18. pii: 10.1038/s41586-020-2937-x. doi: 10.1038/s41586-020-2937-x." journalName="Nature. 2020 Nov 18. pii: 10.1038/s41586-020-2937-x. doi: 10.1038/s41586-020-2937-x."/>
</References>
</Notes>
  Y     –         Unique 6+ Cutters                                                                                                     HO  d                 E             ÿÿÿÿYô?                                                                                                                                                               AÌ<?xml version="1.0"?><Primers recycledIDs="0,3,4,5,7,8,9,11,12,14,17,18,19,20,21,22,23,25,26,27,28,30,31,33,34,35,37,39,40,41,42,43,44,45,46,48,49,50,51,52,53,55,56,57,58,59,60,61,62,63,64,65,66,67,68,72,73,74,77,78,79,80,81,13,71" nextValidID="83"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40" showAdditionalFivePrimeMatches="1" minimumFivePrimeAnnealing="15"/><Primer recentID="1" name="Amp-R" sequence="ATAATACCGCGCCACATAGC" description="Ampicillin resistance gene, reverse primer"><BindingSite location="13466-13485" boundStrand="0" annealedBases="ATAATACCGCGCCACATAGC" meltingTemperature="58"><Component hybridizedRange="13466-13485" bases="ATAATACCGCGCCACATAGC"/></BindingSite><BindingSite simplified="1" location="13466-13485" boundStrand="0" annealedBases="ATAATACCGCGCCACATAGC" meltingTemperature="58"><Component hybridizedRange="13466-13485" bases="ATAATACCGCGCCACATAGC"/></BindingSite></Primer><Primer recentID="2" name="BGH-rev" sequence="TAGAAGGCACAGTCGAGG" description="Bovine growth hormone terminator, reverse primer. Also called BGH reverse"><BindingSite location="4239-4254" boundStrand="0" annealedBases="GGCACAGCGAGG" meltingTemperature="30"><Component bases="TAGAA"/><Component hybridizedRange="4239-4241" bases="GGC"/><Component hybridizedRange="4245-4248" bases="ACAG"/><Component bases="T"/><Component hybridizedRange="4250-4254" bases="CGAGG"/></BindingSite><BindingSite location="9847-9864" boundStrand="1" annealedBases="TAGAAGGCACAGTCGAGG" meltingTemperature="55"><Component hybridizedRange="9847-9864" bases="TAGAAGGCACAGTCGAGG"/></BindingSite><BindingSite simplified="1" location="4245-4254" boundStrand="0" annealedBases="ACAGCGAGG" meltingTemperature="30"><Component bases="TAGAAGGC"/><Component hybridizedRange="4245-4248" bases="ACAG"/><Component bases="T"/><Component hybridizedRange="4250-4254" bases="CGAGG"/></BindingSite><BindingSite simplified="1" location="9847-9864" boundStrand="1" annealedBases="TAGAAGGCACAGTCGAGG" meltingTemperature="55"><Component hybridizedRange="9847-9864" bases="TAGAAGGCACAGTCGAGG"/></BindingSite></Primer><Primer recentID="6" name="CMV-F" sequence="CGCAAATGGGCGGTAGGCGTG" description="Human CMV immediate early promoter, forward primer"><BindingSite location="534-554" boundStrand="0" annealedBases="CGCAAATGGGCGGTAGGCGTG" meltingTemperature="65"><Component hybridizedRange="534-554" bases="CGCAAATGGGCGGTAGGCGTG"/></BindingSite><BindingSite simplified="1" location="534-554" boundStrand="0" annealedBases="CGCAAATGGGCGGTAGGCGTG" meltingTemperature="65"><Component hybridizedRange="534-554" bases="CGCAAATGGGCGGTAGGCGTG"/></BindingSite></Primer><Primer recentID="10" name="EBV-rev" sequence="GTGGTTTGTCCAAACTCATC" description="SV40 polyA terminator, reverse primer"><BindingSite location="11603-11622" boundStrand="0" annealedBases="GTGGTTTGTCCAAACTCATC" meltingTemperature="55"><Component hybridizedRange="11603-11622" bases="GTGGTTTGTCCAAACTCATC"/></BindingSite><BindingSite simplified="1" location="11603-11622" boundStrand="0" annealedBases="GTGGTTTGTCCAAACTCATC" meltingTemperature="55"><Component hybridizedRange="11603-11622" bases="GTGGTTTGTCCAAACTCATC"/></BindingSite></Primer><Primer recentID="15" name="F1ori-F" sequence="GTGGACTCTTGTTCCAAACTGG" description="F1 origin, forward primer"><BindingSite location="6951-6960" boundStrand="0" annealedBases="TCCAACTGG" meltingTemperature="12"><Component bases="GTGGACTCTTGT"/><Component hybridizedRange="6951-6955" bases="TCCAA"/><Component bases="A"/><Component hybridizedRange="6957-6960" bases="CTGG"/></BindingSite><BindingSite location="10420-10441" boundStrand="0" annealedBases="GTGGACTCTTGTTCCAAACTGG" meltingTemperature="57"><Component hybridizedRange="10420-10441" bases="GTGGACTCTTGTTCCAAACTGG"/></BindingSite><BindingSite location="12322-12331" boundStrand="0" annealedBases="TCCAACTGG" meltingTemperature="13"><Component bases="GTGGACTCTTGT"/><Component hybridizedRange="12322-12326" bases="TCCAA"/><Component bases="A"/><Component hybridizedRange="12328-12331" bases="CTGG"/></BindingSite><BindingSite simplified="1" location="6951-6960" boundStrand="0" annealedBases="TCCAACTGG" meltingTemperature="12"><Component bases="GTGGACTCTTGT"/><Component hybridizedRange="6951-6955" bases="TCCAA"/><Component bases="A"/><Component hybridizedRange="6957-6960" bases="CTGG"/></BindingSite><BindingSite simplified="1" location="10420-10441" boundStrand="0" annealedBases="GTGGACTCTTGTTCCAAACTGG" meltingTemperature="57"><Component hybridizedRange="10420-10441" bases="GTGGACTCTTGTTCCAAACTGG"/></BindingSite><BindingSite simplified="1" location="12322-12331" boundStrand="0" annealedBases="TCCAACTGG" meltingTemperature="13"><Component bases="GTGGACTCTTGT"/><Component hybridizedRange="12322-12326" bases="TCCAA"/><Component bases="A"/><Component hybridizedRange="12328-12331" bases="CTGG"/></BindingSite></Primer><Primer recentID="16" name="F1ori-R" sequence="AGGGAAGAAAGCGAAAGGAG" description="F1 origin, reverse primer"><BindingSite location="10210-10229" boundStrand="1" annealedBases="AGGGAAGAAAGCGAAAGGAG" meltingTemperature="57"><Component hybridizedRange="10210-10229" bases="AGGGAAGAAAGCGAAAGGAG"/></BindingSite><BindingSite simplified="1" location="10210-10229" boundStrand="1" annealedBases="AGGGAAGAAAGCGAAAGGAG" meltingTemperature="57"><Component hybridizedRange="10210-10229" bases="AGGGAAGAAAGCGAAAGGAG"/></BindingSite></Primer><Primer recentID="24" name="hU6-F" sequence="GAGGGCCTATTTCCCATGATT" description="Human U6 promoter, forward primer"><BindingSite location="2370-2390" boundStrand="0" annealedBases="GAGGGCCTATTTCCCATGATT" meltingTemperature="56"><Component hybridizedRange="2370-2390" bases="GAGGGCCTATTTCCCATGATT"/></BindingSite><BindingSite location="11999-12008" boundStrand="1" annealedBases="TCCCTGATT" meltingTemperature="12"><Component bases="GAGGGCCTATT"/><Component hybridizedRange="12005-12008" bases="TCCC"/><Component bases="A"/><Component hybridizedRange="11999-12003" bases="TGATT"/></BindingSite><BindingSite simplified="1" location="2370-2390" boundStrand="0" annealedBases="GAGGGCCTATTTCCCATGATT" meltingTemperature="56"><Component hybridizedRange="2370-2390" bases="GAGGGCCTATTTCCCATGATT"/></BindingSite><BindingSite simplified="1" location="11999-12008" boundStrand="1" annealedBases="TCCCTGATT" meltingTemperature="12"><Component bases="GAGGGCCTATT"/><Component hybridizedRange="12005-12008" bases="TCCC"/><Component bases="A"/><Component hybridizedRange="11999-12003" bases="TGATT"/></BindingSite></Primer><Primer recentID="29" name="L4440" sequence="AGCGAGTCAGTGAGCGAG" description="L4440 vector, forward primer"><BindingSite location="6995-7004" boundStrand="0" annealedBases="AGTGGCGAG" meltingTemperature="26"><Component bases="AGCGAGTC"/><Component hybridizedRange="6995-6998" bases="AGTG"/><Component bases="A"/><Component hybridizedRange="7000-7004" bases="GCGAG"/></BindingSite><BindingSite location="11913-11930" boundStrand="1" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="11913-11930" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite><BindingSite location="13954-13963" boundStrand="0" annealedBases="AGTGGCGAG" meltingTemperature="28"><Component bases="AGCGAGTC"/><Component hybridizedRange="13954-13957" bases="AGTG"/><Component bases="A"/><Component hybridizedRange="13959-13963" bases="GCGAG"/></BindingSite><BindingSite simplified="1" location="6995-7004" boundStrand="0" annealedBases="AGTGGCGAG" meltingTemperature="26"><Component bases="AGCGAGTC"/><Component hybridizedRange="6995-6998" bases="AGTG"/><Component bases="A"/><Component hybridizedRange="7000-7004" bases="GCGAG"/></BindingSite><BindingSite simplified="1" location="11913-11930" boundStrand="1" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="11913-11930" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite><BindingSite simplified="1" location="13954-13963" boundStrand="0" annealedBases="AGTGGCGAG" meltingTemperature="28"><Component bases="AGCGAGTC"/><Component hybridizedRange="13954-13957" bases="AGTG"/><Component bases="A"/><Component hybridizedRange="13959-13963" bases="GCGAG"/></BindingSite></Primer><Primer recentID="32" name="LKO.1 5'" sequence="GACTATCATATGCTTACCGT" description="Human U6 promoter, forward primer"><BindingSite location="2541-2560" boundStrand="0" annealedBases="GACTATCATATGCTTACCGT" meltingTemperature="51"><Component hybridizedRange="2541-2560" bases="GACTATCATATGCTTACCGT"/></BindingSite><BindingSite location="9038-9047" boundStrand="0" annealedBases="TGCTTCCGT" meltingTemperature="29"><Component bases="GACTATCATA"/><Component hybridizedRange="9038-9042" bases="TGCTT"/><Component bases="A"/><Component hybridizedRange="9044-9047" bases="CCGT"/></BindingSite><BindingSite simplified="1" location="2541-2560" boundStrand="0" annealedBases="GACTATCATATGCTTACCGT" meltingTemperature="51"><Component hybridizedRange="2541-2560" bases="GACTATCATATGCTTACCGT"/></BindingSite><BindingSite simplified="1" location="9038-9047" boundStrand="0" annealedBases="TGCTTCCGT" meltingTemperature="29"><Component bases="GACTATCATA"/><Component hybridizedRange="9038-9042" bases="TGCTT"/><Component bases="A"/><Component hybridizedRange="9044-9047" bases="CCGT"/></BindingSite></Primer><Primer recentID="36" name="M13 Reverse" sequence="CAGGAAACAGCTATGAC" description="In lacZ gene. Also called M13-rev"><BindingSite location="11682-11698" boundStrand="1" annealedBases="CAGGAAACAGCTATGAC" meltingTemperature="49"><Component hybridizedRange="11682-11698" bases="CAGGAAACAGCTATGAC"/></BindingSite><BindingSite simplified="1" location="11682-11698" boundStrand="1" annealedBases="CAGGAAACAGCTATGAC" meltingTemperature="49"><Component hybridizedRange="11682-11698" bases="CAGGAAACAGCTATGAC"/></BindingSite></Primer><Primer recentID="38" name="M13/pUC Reverse" sequence="AGCGGATAACAATTTCACACAGG" description="In lacZ gene"><BindingSite location="11695-11717" boundStrand="1" annealedBases="AGCGGATAACAATTTCACACAGG" meltingTemperature="58"><Component hybridizedRange="11695-11717" bases="AGCGGATAACAATTTCACACAGG"/></BindingSite><BindingSite simplified="1" location="11695-11717" boundStrand="1" annealedBases="AGCGGATAACAATTTCACACAGG" meltingTemperature="58"><Component hybridizedRange="11695-11717" bases="AGCGGATAACAATTTCACACAGG"/></BindingSite></Primer><Primer recentID="47" name="pBABE 3'" sequence="ACCCTAACTGACACACATTCC" description="SV40 enhancer, reverse primer for pBABE vectors"><BindingSite location="10560-10580" boundStrand="1" annealedBases="ACCCTAACTGACACACATTCC" meltingTemperature="56"><Component hybridizedRange="10560-10580" bases="ACCCTAACTGACACACATTCC"/></BindingSite><BindingSite simplified="1" location="10560-10580" boundStrand="1" annealedBases="ACCCTAACTGACACACATTCC" meltingTemperature="56"><Component hybridizedRange="10560-10580" bases="ACCCTAACTGACACACATTCC"/></BindingSite></Primer><Primer recentID="54" name="pBR322ori-F" sequence="GGGAAACGCCTGGTATCTTT" description="pBR322 origin, forward primer"><BindingSite location="12164-12183" boundStrand="1" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="12164-12183" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite><BindingSite simplified="1" location="12164-12183" boundStrand="1" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="12164-12183" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite></Primer><Primer recentID="69" name="pRS-marker" sequence="CGGCATCAGAGCAGATTGTA" description="pRS vectors, use to sequence yeast selectable marker"><BindingSite location="13883-13902" boundStrand="1" annealedBases="CGGCATCAGAGCAGATTGTA" meltingTemperature="54"><Component hybridizedRange="13883-13902" bases="CGGCATCAGAGCAGATTGTA"/></BindingSite><BindingSite simplified="1" location="13883-13902" boundStrand="1" annealedBases="CGGCATCAGAGCAGATTGTA" meltingTemperature="54"><Component hybridizedRange="13883-13902" bases="CGGCATCAGAGCAGATTGTA"/></BindingSite></Primer><Primer recentID="70" name="Puro-F" sequence="GCAACCTCCCCTTCTACGAGC" description="Puromycin resistance gene, forward primer"><BindingSite location="8809-8829" boundStrand="0" annealedBases="GCAACCTCCCCTTCTACGAGC" meltingTemperature="60"><Component hybridizedRange="8809-8829" bases="GCAACCTCCCCTTCTACGAGC"/></BindingSite><BindingSite simplified="1" location="8809-8829" boundStrand="0" annealedBases="GCAACCTCCCCTTCTACGAGC" meltingTemperature="60"><Component hybridizedRange="8809-8829" bases="GCAACCTCCCCTTCTACGAGC"/></BindingSite></Primer><Primer recentID="75" name="SV40pA-R" sequence="GAAATTTGTGATGCTATTGC" description="SV40 polyA, reverse primer"><BindingSite location="1580-1590" boundStrand="1" annealedBases="GATGCTTTGC" meltingTemperature="21"><Component bases="GAAATTTGT"/><Component hybridizedRange="1585-1590" bases="GATGCT"/><Component bases="A"/><Component hybridizedRange="1580-1583" bases="TTGC"/></BindingSite><BindingSite location="9031-9040" boundStrand="0" annealedBases="ATGCTATTGC" meltingTemperature="32"><Component bases="GAAATTTGTG"/><Component hybridizedRange="9031-9040" bases="ATGCTATTGC"/></BindingSite><BindingSite location="11549-11568" boundStrand="1" annealedBases="GAAATTTGTGATGCTATTGC" meltingTemperature="52"><Component hybridizedRange="11549-11568" bases="GAAATTTGTGATGCTATTGC"/></BindingSite><BindingSite simplified="1" location="1580-1590" boundStrand="1" annealedBases="GATGCTTTGC" meltingTemperature="21"><Component bases="GAAATTTGT"/><Component hybridizedRange="1585-1590" bases="GATGCT"/><Component bases="A"/><Component hybridizedRange="1580-1583" bases="TTGC"/></BindingSite><BindingSite simplified="1" location="9031-9040" boundStrand="0" annealedBases="ATGCTATTGC" meltingTemperature="32"><Component bases="GAAATTTGTG"/><Component hybridizedRange="9031-9040" bases="ATGCTATTGC"/></BindingSite><BindingSite simplified="1" location="11549-11568" boundStrand="1" annealedBases="GAAATTTGTGATGCTATTGC" meltingTemperature="52"><Component hybridizedRange="11549-11568" bases="GAAATTTGTGATGCTATTGC"/></BindingSite></Primer><Primer recentID="76" name="SV40pro-F" sequence="TATTTATGCAGAGGCCGAGG" description="SV40 promoter/origin, forward primer"><BindingSite location="10807-10826" boundStrand="0" annealedBases="TATTTATGCAGAGGCCGAGG" meltingTemperature="57"><Component hybridizedRange="10807-10826" bases="TATTTATGCAGAGGCCGAGG"/></BindingSite><BindingSite location="10830-10841" boundStrand="1" annealedBases="CAGAGGCGAGG" meltingTemperature="35"><Component bases="TATTTATG"/><Component hybridizedRange="10835-10841" bases="CAGAGGC"/><Component bases="C"/><Component hybridizedRange="10830-10833" bases="GAGG"/></BindingSite><BindingSite location="10875-10884" boundStrand="0" annealedBases="GAGGCCAGG" meltingTemperature="27"><Component bases="TATTTATGCA"/><Component hybridizedRange="10875-10880" bases="GAGGCC"/><Component bases="G"/><Component hybridizedRange="10882-10884" bases="AGG"/></BindingSite><BindingSite simplified="1" location="10807-10826" boundStrand="0" annealedBases="TATTTATGCAGAGGCCGAGG" meltingTemperature="57"><Component hybridizedRange="10807-10826" bases="TATTTATGCAGAGGCCGAGG"/></BindingSite><BindingSite simplified="1" location="10830-10841" boundStrand="1" annealedBases="CAGAGGCGAGG" meltingTemperature="35"><Component bases="TATTTATG"/><Component hybridizedRange="10835-10841" bases="CAGAGGC"/><Component bases="C"/><Component hybridizedRange="10830-10833" bases="GAGG"/></BindingSite><BindingSite simplified="1" location="10875-10884" boundStrand="0" annealedBases="GAGGCCAGG" meltingTemperature="27"><Component bases="TATTTATGCA"/><Component hybridizedRange="10875-10880" bases="GAGGCC"/><Component bases="G"/><Component hybridizedRange="10882-10884" bases="AGG"/></BindingSite></Primer><Primer recentID="82" name="WPRE-R" sequence="CATAGCGTAAAAGGAGCAACA" description="WPRE, reverse primer"><BindingSite location="1658-1669" boundStrand="0" annealedBases="AAAGGACAACA" meltingTemperature="26"><Component bases="CATAGCGTA"/><Component hybridizedRange="1658-1663" bases="AAAGGA"/><Component bases="G"/><Component hybridizedRange="1665-1669" bases="CAACA"/></BindingSite><BindingSite location="8981-9001" boundStrand="1" annealedBases="CATAGCGTAAAAGGAGCAACA" meltingTemperature="55"><Component hybridizedRange="8981-9001" bases="CATAGCGTAAAAGGAGCAACA"/></BindingSite><BindingSite simplified="1" location="1658-1669" boundStrand="0" annealedBases="AAAGGACAACA" meltingTemperature="26"><Component bases="CATAGCGTA"/><Component hybridizedRange="1658-1663" bases="AAAGGA"/><Component bases="G"/><Component hybridizedRange="1665-1669" bases="CAACA"/></BindingSite><BindingSite simplified="1" location="8981-9001" boundStrand="1" annealedBases="CATAGCGTAAAAGGAGCAACA" meltingTemperature="55"><Component hybridizedRange="8981-9001" bases="CATAGCGTAAAAGGAGCAACA"/></BindingSite></Primer></Primers>

  Mú<?xml version="1.0"?><Features nextValidID="33"><Feature recentID="0" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="11683-11699" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.53" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9399" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="9325" maxFusedRunOn="9325" detectionMode="exactProteinMatch"><Segment range="9400-9411" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature><Feature recentID="2" name="gp41 peptide" directionality="1" translationMW="1816.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2208" maxFusedRunOn="2208" detectionMode="exactProteinMatch"><Segment range="1861-1905" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;recognized by the 2H10 single-chain llama nanobody&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;antigenic peptide corresponding to amino acids 655 to 669 of the HIV envelope protein gp41 (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/23505368&quot;&gt;Lutje Hulsik et al., 2013&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="KNEQELLELDKWASL"/></Q></Feature><Feature recentID="3" name="P2A" directionality="1" translationMW="1987.15" type="CDS" allowSegmentOverlaps="0" cleavageArrows="8313" consecutiveTranslationNumbering="1" maxRunOn="8913" maxFusedRunOn="8913" detectionMode="exactProteinMatch"><Segment range="8260-8316" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from porcine teschovirus-1 polyprotein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="ATNFSLLKQAGDVEENPGP"/></Q></Feature><Feature recentID="4" name="FLAG" directionality="1" translationMW="1012.98" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="8913" maxFusedRunOn="8913" detectionMode="exactProteinMatch"><Segment range="8227-8250" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DYKDDDDK"/></Q></Feature><Feature recentID="5" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2203-2320" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1443-1676" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="825-950" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9589-9822" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="598-778" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8929-9517" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="U6 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2371-2619" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;RNA polymerase III promoter for human U6 snRNA (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pmc/articles/PMC154217/&quot;&gt;Domitrovich &amp;amp; Kunkel, 2003&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9854-10078" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="11513-11634" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="nucleoplasmin NLS" directionality="1" translationMW="1739.14" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="8913" maxFusedRunOn="8913" detectionMode="exactProteinMatch"><Segment range="8179-8226" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;bipartite nuclear localization signal from nucleoplasmin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="KRPAATKKAGQAKKKK"/></Q></Feature><Feature recentID="15" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10746-10881" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10566-10895" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3839-4050" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="382-580" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-380" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="EM7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10943-10990" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;synthetic bacterial promoter&amp;nbsp;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4069-4078" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="22" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10124-10552" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="12085-12673" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="11707-11723" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="11776-11797" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="26" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="11731-11737" color="#ffffff" type="standard"/><Segment range="11738-11755" color="#ffffff" type="standard"/><Segment name="-35" range="11756-11761" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="27" name="Cas9" directionality="1" translationMW="158441.55" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="8913" maxFusedRunOn="8913" detectionMode="exactProteinMatch"><Segment range="4075-8178" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;generates RNA-guided double strand breaks in DNA&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Cas9 (Csn1) endonuclease from the &lt;i&gt;Streptococcus pyogenes&lt;/i&gt; Type II CRISPR/Cas system&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD"/></Q></Feature><Feature recentID="28" name="Cas9" directionality="1" translationMW="158441.55" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="8913" maxFusedRunOn="8913" detectionMode="exactProteinMatch"><Segment range="4075-8178" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;generates RNA-guided double strand breaks in DNA&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Cas9 (Csn1) endonuclease from the&amp;nbsp;&lt;i&gt;Streptococcus pyogenes&lt;/i&gt;&amp;nbsp;Type II CRISPR/Cas system&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD"/></Q></Feature><Feature recentID="29" name="PuroR" directionality="1" translationMW="21365.28" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" hitsStopCodon="1"><Segment range="8317-8913" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="TEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA*"/></Q></Feature><Feature recentID="30" name="BleoR" directionality="1" translationMW="13796.32" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="11009-11383" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Sh&amp;nbsp;ble&lt;/i&gt; from&amp;nbsp;&lt;i&gt;Streptoalloteichus hindustanus&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to bleomycin, phleomycin, and Zeocinâ„¢&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;antibiotic-binding protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MAKLTSAVPVLTARDVAGAVEFWTDRLGFSRDFVEDDFAGVVRDDVTLFISAVQDQVVPDNTLAWVWVRGLDELYAEWSEVVSTNFRDASGPAMTEIGEQPWGREFALRDPAGNCVHFVAEEQD*"/></Q></Feature><Feature recentID="31" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="13635" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="12844-13635" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="13636-13704" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="32" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="13705-13809" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   )<?xml version="1.0"?><CustomEnzymeSets/>
